Natural Drug Discovery and Development GroupPublications

Publications (Year 2014 - 2025) [Full Publications List for Prof. Kwok: https://fhs.um.edu.mo/en/prof-henry-hang-fai-kwok-full-publications/]

Luo S., Li J., Zhou Y., Zhai Z., Li Q., Huang Z., He W., Zhong K., Kong B., Xia Z., Kwok H. F.*, Zhu L.* (2025) Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress. Ecotoxicology and Environmental Safety 290: 117594.

2014 - 2024

Ren Y., Liu Y., Pang R., Xu G., Lei Y., Kwok H. F., Wu Y., Cao Z. (2024) ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin-mediated degradation and facilitate viral replication. Frontiers in Cellular and Infection Microbiology 14: 1502770.
Lin Z., Pan R., Wu L., Zhu F., Fang Q., Kwok H. F.*, Lu X* (2024) AFP-HSP90 mediated MYC/MET activation promotes tumor progression in hepatocellular carcinoma and gastric cancers. Cancer Cell International 24(1): 283.
Yang H., Chen Y., Wang L., Gan B., Yu L., Ren R., Kwok H. F., Wu Y., Cao Z. (2024) The fungal secretory peptide micasin induces itch by activating MRGPRX1/C11/A1 on peripheral neurons. Journal of Investigative Dermatology (In Press)
Cheong H. H., Zuo W., Chen J., Un C. W., Si Y. W., Wong K. H., Kwok H. F.*, Siu S.* (2024) Identification of anticancer peptides from the genome of Candida Albicans: In-silico screening, in-vitro and in-vivo validations. Journal of Chemical Information and Modeling 64(15): 6174–618.
Lin Z., Assaraf Y. G., Kwok H. F.* (2024) Peptides for microbe-induced cancer: latest therapeutic strategies and their advanced technologies. Cancer and Metastasis Reviews 43: 1315-1336.
Li J., Assaraf Y. G., Zuo W., Lin Z., Leong K. W., Zhao Q.*, Zhu L.*, Kwok H. F.* (2024) Nanoenabled intracellular zinc bursting for efficacious reversal of gefitinib resistance in lung cancer. International Journal of Biological Sciences 20(8): 3028-3045.
Wu Q., Song M., Luo S., Guo L., Zhang Q*., Kwok H. F.* (2024) Unveil the mechanism for EHMT -- A novel triterpenoid inhibits proliferation and induces apoptosis in colon cancer through ROS-mediated JNK signaling pathway. Biomedicine & Pharmacotherapy 174: 116469.
Xu Y., Kwok H. F.*, Chen L.* (2024) TRIM11: A powerful guardian of proteostasis. The Innovation Life 2(1): 100048.
He S., Qu Q., Chen X., Zhao L., Jiao Z., Wan Z., Kwok H. F., Qu S. (2024) Downregulation of Ambra1 by altered DNA methylation exacerbates dopaminergic neuron damage in a fenpropathrin-induced Parkinson-like mouse model. Ecotoxicology and Environmental Safety 271: 115995.
Kwok H. F.* (2024) Editorial: Regulating cell cycle-related activities -- The right target for cancer therapy. Seminars in Cancer Biology 98: 64-65.
Zuo W., Kwok H. F.* (2024) Chapter 22 Design of bioengineered peptides/proteases as anti-cancer reagents with integrated omics and machine learning approaches. In Salvatore Santamaria (Ed.), Proteases and Cancer (Methods Mol Biol. 2747: 295-309). Berlin, Germany: Springer Nature.
Qin H., Zuo W., Luo S., Ge L., Wang L., Chen X., Ma. C., Li H. Chen T., Zhou M., Kwok H. F.* (2024) Design of novel analogues of t-DPH-1 with reduced cytotoxicity, taking the three conserved characteristics of the Dermaseptin family as the feasible starting point. Arabian Journal of Chemistry 17(1): 105420.
Xia Z., He D., Yu Y., Kwok H. F.*, Cao Z.* (2023) Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers. Pharmacological Research 197: 109679.
Zou L.^, Zheng D.^, Yao Y., Wen F., Li D., Yang Y., Yang W., Balamurugan S., Kwok H. F., Li H. (2023) Polyphenols modulate microalgae metabolism with a particular increment in lipid accumulation. Fuel 352: 129085.
Guo L.^, Li B.^, Wong S. W., Chen M., Xu Q, Ge L*, Kwok H. F.* (2023) Enzyme-catalyzed high-performing reaction with in-situ amplified photocurrent on carbon-functionalized inorganic photoanode for immunosensing. Biosensors and Bioelectronics 236: 115404.
Labrou N. E.*, Kwok H. F.*, Zhang Q.* (2023) Editorial: Insights in protein biochemistry: protein biophysics 2022. Frontiers in Molecular Biosciences 10: 1207184.
Qin H., Zuo W., Ge L., Siu S. W. I., Wang L., Chen X., Ma C., Chen T., Zhou M.*, Cao Z.*, Kwok H. F.* (2023) Discovery and analysis of novel antimicrobial peptide B1AW from Amolops wuyiensis and improving membrane-binding affinity through construction of lysine-introduced analogue. Computational and Structural Biotechnology Journal 21: 2960-2972.
Wang L., Sun F., Hu J., Zuo W., Zheng Y., Wu Y., Kwok H. F.*, Cao Z.* (2023) The tick saliva peptide HIDfsin2 promotes the tick-borne virus SFTSV replication in vitro by enhancing p38 signal pathway. Archives of Toxicology 97(6):1783-1794.
Kwok H. F., Yamamoto K, de Groot R, Scilabra S. D., Santamaria S. (2023) Editorial: ADAM, ADAMTS and astacin proteases: Challenges and breakthroughs in the -Omics era -- Volume II. Frontiers in Molecular Biosciences 10: 1172288.
Dashevsky D., Baumann K., Undheim E. A. B., Nouwens A., Ikonomopoulou M. P., Schmidt J. O., Ge L., Kwok H. F., Rodriguez J., Fry B. G. (2023) Functional and Proteomic Insights into Aculeata Venoms. Toxins 15(3): 224.
Kwok H. F.* (2023) Editorial: New mechanistic insights into cancer precision medicine. Frontiers in Pharmacology 14: 1159703.
Chen P., Song Y., Tang L., Zhong W., Zhang J., Cao M., Chen J., Cheng G., Li H., Fan T., Kwok H. F., Wang J., Yang C., Xiao W. (2023) Tributyltin chloride (TBTCL) induces cell injury via dysregulation of endoplasmic reticulum stress and autophagy in Leydig cells. Journal of Hazardous Materials 448: 130785.
Wu Q., Chen P., Li J., Lin Z., Zhang Q., Kwok H. F.* (2023) Inhibition of bladder cancer growth with Homoharringtonine by inactivating integrin α5/β1-FAK/Src axis: A novel strategy for drug application. Pharmacological Research 188: 106654.
Mughal M. J., Bhadresha K., Kwok H. F.* (2023) CDK inhibitors from past to present: a new wave of cancer therapy. Seminars in Cancer Biology 88: 106-122.
Lv J., Yuan K., Lu, G., Li H., Kwok H. F., Yang W. (2023) Responses of ABCB and ABCC transporters to the toxic dinoflagellate Prorocentrum lima in the mussel Perna viridis. Aquatic Toxicology 254: 106368.
Li J., Zhu L., Kwok H. F.* (2023) Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment. Drug Resistance Updates 66: 100904.
Li B., Guo L., Ge L., Kwok H. F.* (2023) Pearson's principle-inspired hollow metal sulfide for amplified photoelectrochemical immunoassay for disease-related protein. Biosensors and Bioelectronics 221: 114210.
Zhu L., Li J., Guo Z., Kwok H. F., Zhao Q. (2022) Synergistic combination of targeted nano-nuclear-reactors and anti-PD-L1 nanobodies evokes persistent T cell immune activation for cancer immunotherapy. Journal of Nanobiotechnology 20: 521.
Guo L., Tang X., Wong S. W., Guo, A., Lin Y.*, Kwok H. F.* (2022) Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications. Frontiers in Pharmacology 13: 1022129.
Li J., Chen P., Wu Q., Guo L., Leong K. W., Chan K. I., Kwok H. F.* (2022) A novel combination treatment of antiADAM17 antibody and erlotinib to overcome acquired drug resistance in non-small cell lung cancer through the FOXO3a/FOXM1 axis. Cellular and Molecular Life Sciences 79: 614.
Kwok H. F.*, Walker B., Shaw C. (2022) Editorial: Proteases -- From Basic Structure to Function to Drug Design as Targeted Therapy. Biology 11(11): 1680.
Lin J., Liu G., Chen L., Kwok H. F.*, Lin Y.* (2022) Targeting lactate-related cell cycle activities for cancer therapy. Seminars in Cancer Biology 86: 1231-1243.
Wang Q., Weng S., Sun Y., Chi L., Lin Y., Zhong W., Xue F., Kwok H. F.*, Lin Y.* (2022) High DAPK1 expression promotes tumor metastasis of gastric cancer. Biology 11(10): 1488.
Lin Z., Kwok H. F.* (2022) RUNDC3A/SNAP25/Akt signaling mediates tumor progression and chemoresistance in gastric neuroendocrine carcinoma. Cell Death & Disease 13(10): 840.
Yang M., Miao Y. R., Xie G. Y., Luo M., Hu H., Kwok H. F., Feng J., Guo A. Y. (2022) ICBatlas: A comprehensive resource for depicting immune checkpoint blockade therapy characteristics from transcriptome profiles. Cancer Immunology Research 10(11): 1398-1406.
Lin Y.*, Kwok H. F.* (2022) Editorial: Exercise and Cancer: From Clinical Association to Mechanistic Insights. Frontiers in Molecular Biosciences 9: 1007228.
Kwok H. F.* (2022) Editorial: Drug Discovery from Natural Sources --Animal Venoms, Plants, Bacteria and Fungi. Frontiers in Molecular Biosciences 9: 998676.
Chen P., Wang W., Wong S. W., Li J., Wu Q., Zhang S. D., Lin Y.*, Kwok H. F.* (2022) RUNDC3A regulates SNAP25-mediated chemotherapy resistance by binding AKT in gastric neuroendocrine carcinoma (GNEC). Cell Death Discovery 8(1): 296.
Kwok H. F.*, Zhang Q.* (2022) Editorial: Insights in Protein Chemistry and Enzymology - 2021. Frontiers in Molecular Biosciences 9: 944975.
Kwok H. F.* (2022) The significance of advanced COVID-19 diagnostic testing in pandemic control measures. International Journal of Biological Sciences 18(12): 4610-4617.
Yan J., Zhang B., Zhou M., Kwok H. F.*, Siu S. W. I.* (2022) Multi-Branch-CNN: classification of ion channel interacting peptides using multi-branch convolutional neural network. Computers in Biology and Medicine 147: 105717.
Mughal M. J., Chan K. I., Mahadevappa R., Wong S. W., Wai, K. C., Kwok H. F.* (2022) Over-activation of Minichromosome Maintenance Protein 10 promotes genomic instability in early stages of breast cancer progression. International Journal of Biological Sciences18(9): 3827-3844.
Dias I., Cao Z., Kwok H. F.* (2022) Adamalysins in COVID-19 – Potential mechanisms behind exacerbating the disease. Biomedicine & Pharmacotherapy 150: 112970.
Ye Z., Zhou X., Xi X., Zai Y., Zhou M., Chen X., Ma C., Chen T., Wang L., Kwok H. F.* (2022) In Vitro & In Vivo studies on identifying and designing Temporin-1CEh from the skin secretion of Rana chensinensis as the optimised antibacterial prototype drug. Pharmaceutics 14(3): 604.
Li J., Kwok H. F.* (2022) The intricate roles of RCC1 in normal cells and cancer cells. Biochemical Society Transactions 50(1):83-93.
Li B., Guo L., Chen M., Guo Y., Ge L., Kwok H. F.* (2022) Single-atom Pt-anchored Zn0.5Cd0.5S boosted photoelectrochemical immunoassay of prostate-specific antigen. Biosensors and Bioelectronics 202: 114006.
Wang L., Xia Z., Tang W., Sun Y., Wu Y., Kwok H. F.*, Sun F.*, Cao Z.* (2022) p38 activation and viral infection. Expert Reviews in Molecular Medicine 24: e4.
Kwok H. F.*, Shaw C., Walker B. (Ed.) (2021) Proteases -- From Basic Structure to Function to Drug Design as Targeted Therapy (pp. 1-93). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI) ISBN 978-3-0365-2575-4.
Yamamoto K., de Groot R., Scilabra S.D., Kwok H. F., Santamaria S. (2021) Editorial: ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era. Frontiers in Molecular Biosciences 8: 780242.
Li B., Pu W., Weng L., Lyu P., Xu H., Zheng W., Ge L., Kwok H. F., Wu Q. (2021) Aptamer-functionalized Ti₃C₂-MXene Nanosheets with One-step Potentiometric Detection of Programmed Death-ligand 1. Electroanalysis 33: 1-7.
Song M., Qiao T., Wu Q., Kwok H. F., Chan G., Lin L, Zhang X, Ye W., He S., Zhang Q. (2021) Biflavonoids from the twigs and leaves of Cephalotaxus oliveri Mast. and their α-glucosidase inhibitory activity. Natural Product Research DOI: 10.1080/14786419.2021.1958328
Chen Y., Xi X., Ma C., Zhou M., Chen X., Ye Z., Ge L., Wu Q., Chen T., Wang L., Kwok H. F.* (2021) Structure–Activity Relationship and Molecular Docking of a Kunitz-Like Trypsin Inhibitor, Kunitzin-AH, from the Skin Secretion of Amolops hainanensis. Pharmaceutics 13(7): 966.
Zuo W., Kwok H. F.* (2021) Development of Marine-Derived Compounds for Cancer Therapy. Marine Drugs 19(6): 342.
Mughal M. J., Kwok H. F.* (2021) Multidimensional Role of Bacteria in Cancer: Mechanisms Insight, Diagnostic, Preventive and Therapeutic Potential. Seminars in Cancer Biology 86: 1026-1044.
Sun F.^, Mu C.^, Kwok H. F.^, Xu J., Wu Y., Liu W., Sabatier J., Annweiler C., Li X., Cao Z., Xie Y. (2021) Capivasertib restricts SARS-CoV-2 cellular entry: a potential clinical application for COVID-19. International Journal of Biological Sciences 17(9): 2348-2355.
Wei R., Wu Q., Ai N., Wang L., Zhou M., Shaw C., Chen T., Ye R. D., Ge W., Siu S. W. I., Kwok H. F.* (2021) A novel bioengineered fragment peptide of Vasostatin-1 exerts smooth muscle pharmacological activities and anti-angiogenic effects via blocking VEGFR signalling pathway. Computational and Structural Biotechnology Journal 19: 2664-2675.
Zai Y., Xi X., Ye Z., Ma C., Zhou M., Chen X., Siu S.W.I., Chen T., Wang L., Kwok H. F.* (2021) Aggregation and its influence on the bioactivities of a novel antimicrobial peptide, Temporin-PF, and its analogues. International Journal of Molecular Sciences 22: 4509.
Kwok H. F.* (2021) Review of Covid-19 vaccine clinical trials - A puzzle with missing pieces. International Journal of Biological Sciences 17(6): 1461-1468.
Kwok H. F. (Ed.)* (2021) Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases (pp. 1-180). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI) ISBN 978-3-0365-0386-8.
Li B., Ge L., Lyu P., Chen M., Zhang X., Xie S., Wu Q., Kwok H. F.* (2021) Handheld pH meter-assisted immunoassay for C-reactive protein using glucose oxidase-conjugated dendrimer loaded with platinum nanozymes. Microchimica Acta 188(1): 14.
Kwok H. F.* (2020) Novel natural-based biomolecules discovery for tackling chronic diseases. Biomolecules 10(12): 1674.
Chen Y., Li B., Lyu P., Kwok H. F., Ge L., Wu Q. (2020) Boronate ester bond-based potentiometric aptasensor for screening carcinoembryonic antigen-glycoprotein using nanometer-sized CaCO₃ with ion-selective electrode. Analytical and Bioanalytical Chemistry 413(4): 1073-1080.
Xie J., Chen P., Xie. X, Sun Y., Huang Z., Wei R., Maio Z., Wang Q., Zhang S. D., Wong K. H., Lin Y.*, Huang C.*, Kwok H. F.* (2020) Exploration of Gastric Neuroendocrine Carcinoma (GNEC) specific signaling pathways involved in chemoresistance via transcriptome and in vitro analysis. Computational and Structural Biotechnology Journal 18: 2610-2620.
Ma R., Kwok H. F.* (2020) New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer therapy. Seminars in Cancer Biology 80: 356-369.
Zhou X., Liu Y., Gao Y., Wang Y., Xia Q., Zhong R., Ma C., Zhou M., Xi X.*, Shaw C., Chen T., Wu D., Kwok H. F.*, Wang L. (2020) Enhanced Antimicrobial Activity of N-Terminal Derivatives of a Novel Brevinine-1 Peptide from The Skin Secretion of Odorrana schmackeri. Toxins 12(8): 484.
Yang S., Cao B., Zhou G., Zhu L., Wang L., Zhang L., Kwok H. F., Zhang Z., Zhao Q. (2020) Targeting the B7-H3 Immune Checkpoint with Specific CAR-engineered NK-92 Cells Exhibits Potent Cytotoxicity against Non-Small Cell Lung Cancer. Frontiers in Pharmacology 11: 1089.
Gutsaeva D. R., Shalaby L., Powell F. L., Thounaojam M. C., Abouhish H., Wetzstein S. A., Jadeja R. N., Kwok H. F., Martin P. M., Bartoli M. (2020) Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neuronal and Vascular Damage. International Journal of Molecular Sciences 21(15): 5379.
Zhou X., Xu J., Zong R., Ma C., Zhou M., Cao Z., Xi X.*, Shaw C., Chen T., Wang L., Kwok H. F.* (2020) Pharmacological Effects of a Novel Bradykinin-Related Peptide (RR-18) from the Skin Secretion of the Hejiang Frog (Ordorrana hejiangensis) on Smooth Muscle. Biomedicines 8(7): 225.
Ma R., Ren Z., Li B., Siu S. W. I., Chen G., Kwok H. F.* (2020) Novel venom-based peptides (P13 & its derivative -- M6) to maintain self-renewal of human embryonic stem cells by activating FGF and TGF-ß signaling pathways. Stem Cell Research & Therapy 11: 243.
Guo L., Wei R., Lin Y.*, Kwok H. F.* (2020) Clinical and recent patents applications of PD-1/PD-L1 targeting immunotherapy in cancer treatment — current progress, strategy and future perspective. Frontiers in Immunology 11: 1508.
Li J., Kwok H. F.* (2020) Current strategies for treating NSCLC: from biological mechanisms to clinical treatment. Cancers 12(6): 1587.
Yueng L., Anderson J. M. L., Wee J. L., Demaria M. C., Finsterbusch M., Liu Y. S., Hall P., Smith B. C., Danker W., Elgss K., Wicks I. P., Kwok H. F., Wright M. D., Hickey M. (2020) Leukocyte tetraspanin CD53 restrains α3 integrin mobilization and facilitates cytoskeletal remodelling and transmigration in mice. Journal of Immunology 205(2): 521-532.
Wu Q., Wong J. P. C., Kwok H. F.* (2020) Putting the brakes on tumorigenesis with natural products of plant origin: Insights into the molecular mechanisms of actions and immune targets for bladder cancer treatment. Cells 9(5): 1213.
Demaria M. C., Yeung L., Peeters R., Wee J. L., Mihaljcic M., Jones E. L., Nasa Z., Alderuccio F., Hall P., Smith B. C., Binger K. J., Hammerling G., Kwok H. F., Newman A., Ager A., van Spriel A., Hickey M. J., Wright M. D. (2020) Tetraspanin CD53 promotes lymphocyte recirculation by stabilising L-selectin surface expression. iScience 23(5): 101104.
Xie S., Li B., Lyu P., Kwok H. F., Ge L., Wu Q. (2020) A new voltammetric immunosensing platform for prostate-specific antigen based on the Cu(II)-pyrophosphate ion chelation reaction. New Journal of Chemistry 44: 3820-3823.
Shalaby L., Thounaojam M., Tawfik A., Li J., Hussein K., Jahng J. W., Al-Shabrawey M., Kwok H. F., Bartoli M., Gutsaeva, D. (2020) Role of endothelial ADAM17 in early vascular changes associated with diabetic retinopathy. Journal of Clinical Medicine 9(2): 400.
Scheib H., Nekaris A., Rode J., Ragnarsson L., Baumann K., Dobson J., Wirdateti W., Nouwens A., Nijman V., Martelli P., Ma R., Lewis R., Kwok H. F.*, Fry B.* (2020) A structural comparison of the cat dander allergenic protein Fel d1 and the brachial gland secretion protein from the Javan slow loris Nycticebus javanicus. Toxins 12(2): 86.
Cheng Y., Sun F., Li S., Gao M., Wang L., Sarhan M., Abdel-Rahman M. A., Li W., Kwok H. F., Wu Y., Cao Z. (2020) Inhibitory activity of a scorpion defensin BmKDfsin3 against hepatitis C virus. Antibiotics 9(1): 33.
Ma R., Wong S. W., Ge L., Shaw C., Siu S. W. I., Kwok H. F.* (2019) In vitro & molecular dynamic stimulation study to explore physicochemical parameters for antibacterial peptide to become potent anticancer peptide. Molecular Therapy -- Oncolytics 16: 7-19.
Kwok H. F. (Ed.)* (2019) Venom toxins as potential targeted therapy (pp. 1-167). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI) ISBN 978-3-03921-190-6.
Yang Z., Chan K. I., Kwok H. F.*, Tam K. Y.* (2019) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-TKI–Mediated Anticancer Activity in NSCLC. Translational Oncology 12(11): 1516-1524.
Zhou X., Shi D., Zhong R., Ye Z., Ma C., Zhou M., Xi X., Wang L., Chen T., Kwok H. F.* (2019) Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and its Truncated Analogues. Biomolecules 9(6): 249.
Kwok H. F.* (2019) Venom toxins as potential targeted therapies. Toxins 11(6): 338.
Li B., Lyu P., Xie S., Qin H., Pu W., Xu H., Chen T., Shaw C., Ge L.*, Kwok H. F.* (2019) LFB: A novel antimicrobial Brevinin-like peptide from the skin secretion of the Fujian large headed frog, Limnonectes fujianensi. Biomolecules 9(6): 242.
Chen P., Wang Q., Xie J.*, Kwok H. F.* (2019) Signaling networks and the feasibility of computational analysis in gastroenteropancreatic neuroendocrine tumors. Seminars in Cancer Biology 58: 80-89.
Debono J., Bos M. H. A., Coimbra F., Frank N., Kwok H. F.*, Fry B. G.* (2019) Basal but divergent: Clinical implications of differential coagulotoxicity in a clade of Asian vipers. Toxicology In Vitro 58: 195-206.
Ge L., Li B., Xu H., Pu W., Kwok H. F.* (2019) Backfilling rolling cycle amplification with enzyme-DNA conjugates on antibody for portable electrochemical immunoassay with glucometer readout. Biosensors and Bioelectronics 132: 210-216.
Li B., Pu W, Xu H., Ge L.*, Kwok H. F.*, Hu L. (2019) Magneto-controlled flow-injection device for electrochemical immunoassay of alphafetoprotein on magnetic beads using redox-activeferrocene derivative polymer nanospheres. Analyst 144: 1443-1441.
Lyu P., Kwok H. F.* (2019) High-throughput strategy accelerates the progress of marine anticancer peptide drug development. Recent Patents on Anti-Cancer Drug Discovery 14(1): 2-4.
Liu M., Liu X., Huang Z., Tang X., Lin X., Xu Y., Kwok H. F.*, Lin Y.*, Feng S* (2019) Rapid discrimination of colon cancer cells with single base mutation in KRAS gene segment using laser tweezers Raman spectroscopy. Journal of Biophotonics 12(3): e201800332.
Mughal M. J., Mahadevappa R., Kwok H. F.* (2018) DNA replication licensing proteins: saints and sinners in cancer. Seminars in Cancer Biology 58: 11-21.
Debono⁠ J., Bos⁠ M. H. A., Nouwens⁠ A., Ge⁠ L.⁠, Frank⁠ N., Kwok⁠ H. F.⁠*, Fry⁠ B. G.⁠* (2018) Habu coagulotoxicity: Clinical implications of the functional diversification of Protobothrops snake venoms upon blood clotting factors. Toxicology In Vitro 55: 62-74.
Rajendran B. K., Suresh M. X., Bhaskaran S. P., Harshitha Y., Gaur U., Kwok H. F.* (2018) Pharmacoinformatic approach to explore the antidote potential of phytochemicals on bungarotoxin from Indian krait, Bangarus caeruleus. Computational and Structural Biotechnology Journal 16: 450-461.
Wei R., Guo L., Wang Q., Miao J., Kwok H. F.*, Lin Y.* (2018) Targeting PD-L1 Protein: Translation, Modification and Transport. Current Protein and Peptide Science 20: 82-91.
Lyu P., Ge L., Ma R., Wei R., McCrudden C. M., Chen T., Shaw C., Kwok H. F.* (2018) Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide -- PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer. Scientific Reports 8(1):14502.
Mahadevappa R., Neves H., Yuen S. M., Jameel M., Bai Y., Yuen H. F., Zhang S. D., Zhu Y., Lin Y., Kwok H. F.* (2018) DNA replication licensing protein MCM10 promotes tumor progression and is a novel prognostic biomarker and potential therapeutic target in breast cancer. Cancers 10(9): 282.
Tin Y., Chen X., Ma C., Xi X., Wang L., Zhou M., Burrows J. F., Kwok H. F., Chen T. (2018) Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii. Toxins 10(8): 320.
Li B., Lyu P., Xi X., Ge L., Mahadevappa R., Shaw C., Kwok H. F.* (2018) Triggering of cancer cell cycle arrest by a novel scorpion venom-derived peptide -- Gonearrestide. Journal of Cellular and Molecular Medicine 22(9): 4460-4473.
Coimbra F. C. P., Dobson J., Zdenek C. N., Op den Brouw B., Hamilton B., Debono J., Masci P., Frank N., Ge L, Kwok H. F., Fry B. G. (2018) Does size matter? Venom proteomic and functional comparison between night adder species (Viperidae: Causus) with short and long venom glands. Comp Biochem Physiol C Toxicol Pharmacol 211: 7-14.
Wei R., Wong J. P. C., Lyu P., Xi X., Tong O. L. H., Zhang S. D., Yuen H. F., Shirasawa S., Kwok H. F.* (2018) In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer. Journal of Cellular and Molecular Medicine 22(9): 4097-4105.
Huang Y., Zhang Y., Ge L., Lin Y.*, Kwok H. F.* (2018). The Role of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma. Cancers 10(3): 82.
Goldenberg J., Cipriani V., Jackson T. N. W., Arbuckle K., Debono J., Dashevsky D., Panagides N., Ikonomopoulou M. P., Koludarov I., Li B., Santana R. C., Nouwens A., Jones A., Hay C., Dunstan N., Allen L., Bush B., Miles J. J., Ge L., Kwok H. F.*, Fry B. G.* (2018) Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis). Comp Biochem Physiol C Toxicol Pharmacol 205: 53-61.
Perry B. I., Cooray S. E., Mendis J., Purandare K., Wijeratne A., Manjubhashini S., Dasari M., Esan F., Gunaratna I., Naseem R. A., Hoare S., Chester V., Roy A., Devapriam J., Alexander R., Kwok H. F. (2018) Problem behaviours and psychotropic medication use in intellectual disability: a multinational cross-sectional survey. J Intellect Disabil Res 62(2):140-149.
Wang Q., Lin W., Tang X., Li S., Guo L., Lin Y.*, Kwok H. F.* (2017) The roles of microRNAs in regulating the expression of PD-1/PD-L1 immune checkpoint. International Journal of Molecular Sciences 18(12): 2540.
Zhong H., Chen B., Neves H., Xing J., Ye Y., Lin Y., Zhuang G., Zhang S. D., Huang J., Kwok H. F.* (2017) Expression of minichromosome maintenance genes in renal cell carcinoma. Cancer Management and Research 9: 637-647.
Wong J. P. C., Wei R., Lyu P., Tong O. L. H., Zhang S. D., Wen Q., Yuen H. F., El-Tanani M., Kwok H. F.* (2017) Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer. International Journal of Biological Sciences 13(11): 1373-1386.
Ling Y., Chen J., Guo L., Wang C., Tan W., Wen Q., Zhang S. D., Deng G.*, Lin Y.*, Kwok H. F.* (2017) β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development. Scientific Reports 7(1): 13404.
Ma R., Mahadevappa R., Kwok H. F.* (2017) Venom-based peptide therapy: insights into anti-cancer mechanism. Oncotarget 8(59): 100908-100930.
Guo L., Lin Y., Kwok H. F.* (2017) The function and regulation of PD-L1 in immunotherapy. ADMET and DMPK 5(3): 159-172 .
Kawai T., Takayanagi T., Forrester S. J., Preston K. J., Obama T., Tsuji T., Kobayashi T., Boyer, M. J., Copper H. A., Kwok H. F., Hashimoto T., Scalia R., Rizzo V., Eguchi S. (2017) Vacular ADAM17 is required for angiotensin II/β-aminopropionitrile-induced abdominal aortic aneurysm. Hypertension 70(5): 959-963.
Koludarov I., Jackson T. N. W., Brouw B., Dobson J., Dashevsky D., Arbuckle K., Clemente C. J., Stockdale E. J., Cochran C., Debono J., Stephens C., Panagides N., Li B., Manchadi M. R., Violette A., Fourmy R., Hendrikx I., Nouwens A., Clements J., Martelli P., Kwok H. F., Fry B. G. (2017) Enter the Dragon: The Dynamic and Multifunctional Evolution of Anguimorpha Lizard Venoms. Toxins 9(8): 242.
Mahadevappa R., Ma R., Kwok H. F.* (2017) Venom peptides -- Improving specificity for cancer therapy. Trends in Cancer 3(9): 611-614.
Wei R., Wong J.P.C., Kwok H. F.* (2017) Osteopontin -- a promising biomarker for cancer therapy. Journal of Cancer 8(12): 3173-2183.
Li L., Guo L., Wang Q., Liu X., Zeng Y., Wen Q., Zhang S., Kwok H. F.*, Lin Y.*, Liu J.* (2017) DAPK1 as an independent prognostic marker in liver cancer. PeerJ 5: e3568.
Wong J.P.C., Li B., Kwok H. F.* (2017) Venom Peptides and Toxins - A Prospective Spearhead in Cancer Treatment. Combinatorial Chemistry High Throughput Screen 20(5): 357-375.
Neves H., Kwok H. F.* (2017) In sickness and in health: The many roles of the minichromosome maintenance proteins. BBA - Reviews on Cancer 1868(1): 295-308.
Ye J., Yuen S. M., Murphy G., Xie R.*, Kwok H. F.* (2017) Anti-Tumour Effects of a 'Human & Mouse Cross-Reactive' Anti-ADAM17 Antibody in a Pancreatic Cancer Model In Vivo. European Journal of Pharmaceutical Sciences 110: 62-69.
Debono J., Dobson J., Casewell N.R., Romilio A., Li B., Kurniawan N., Mardon K., Weisbecker V., Nouwens A., Kwok H. F., Fry B. G. (2017) Coagulating Colubrids: Evolutionary, Pathophysiological and Biodiscovery Implications of Venom Variations between Boomslang (Dispholidus typus) and Twig Snake (Thelotornis mossambicanus). Toxins 9(5): pii: E171.
Cipriani V., Debono J., Goldenberg J., Jackson T. N. W., Arbuckle K., Dobson J., Koludarov I., Li B., Hay C., Dunstan N., Allen L., Hendrikx I., Kwok H. F., Fry B. G. (2017) Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes (Pseudonaja). Comp Biochem Physiol C Toxicol Pharmacol 197: 53-60.
Xie J. Y., Chen P. C., Zhang J. L., Gao Z. S., Neves H., Zhang S. D., Wen Q., Chen W. D., Kwok H. F.*, Lin Y.* (2017) The prognostic significance of DAPK1 in bladder cancer. PLoS One 12(4): e0175290.
Mahadevappa R., Neves H., Yuen S. M., Bai Y., McCrudden C. M., Yuen H. F., Wen Q, Zhang S. D., Kwok H. F.* (2017) The prognostic significance of Cdc6 and Cdt1 in breast cancer. Scientific Reports 7(1): 985.
Mahadevappa R., Kwok H. F.* (2017) Phytochemicals - A Novel and Prominent Source of Anti-cancer Drugs against Colorectal Cancer. Combinatorial Chemistry High Throughput Screen 20: 376-394.
Lyu P., Zhang S. D., Yuen H. F., McCrudden C. M., Wen Q., Chan K. W., Kwok H. F.* (2017) Identification of TWIST-interacting genes in prostate cancer. Science China Life Sciences 60(4): 386-396.
Xiao Y., Yan W., Guo L., Meng C., Li B., Neves H., Chen P., Li L., Huang Y., Kwok H. F.*, Lin Y.* (2017) Digitoxin Synergized with Sorafenib to Inhibit Hepatocelluar Carcinoma Cell Growth and Migration. Molecular Medicine Reports 15(2): 941-947.
Yuen S. M. and Kwok H. F.* (2017) Temporal establishment of neural cell identity in vivo and in vitro. Journal of Tissue Engineering and Regenerative Medicine 11(9): 2582-2589.
Li B., McCrudden C. M., Yuen H. F., Xi X., Lyu P., Chan K. W., Zhang S. D., Kwok H. F.* (2016) CD133 in brain tumor: the prognostic factor. Oncotarget 8(7): 11144-11159.
Takayanagi T., Forrester S. J., Kawai T., Obama T., Tsuji T., Elliott K. J., Nuti E., Rossello A., Kwok H. F., Scalia R., Rizzo V., Eguchi S. (2016) Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Hypertension 68: 949-955.
Shi D., Hou X., Wang L., Gao Y., Wu D., Xi X.*, Zhou M.*, Kwok H. F.*, Duan J., Chen T., Shaw C. (2016) Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor. Toxins 8(5): 144.
Botkjaer K. A.*, Kwok H. F*., Terp M. G., Karatt-Vellatt A., Santamaria S., McCafferty J., Andreasen P. A., Itoh Y., Ditzel H. J., Murphy G.* (2016) Development of specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo. Oncotarget 7(13): 16773-16792.
Zhang S. D., McCrudden C. M., Yuen H. F., Leung K. L., Hong W. J., Kwok H. F.* (2016) Association of TAZ, AXL and CTGF expression with clinicopathological parameters in colon cancer. Oncology Letters 11: 1223-1229.
Zhang S. D., McCrudden C. M., Kwok H. F.* (2015) Prognostic significance of combining VEGFa, FLT1 and KDR mRNA expressions in lung cancer. Oncology Letters 10: 1893-1901.
Zhao D., Guo L., Neves H., Yuen H. F., Zhang S. D., McCrudden C. M., Wen Q., Zhang J., Zeng Q., Kwok H. F*., Lin Y.* (2015) The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer. OncoTargets and Therapy. 8: 1707-1717.
Fry B. G., Roelants K., Jackson T. N. W., Takacs Z., Reeks T., Kwok H. F.* (2015) Chapter 18 B-Type natriuretic peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 312-317). Oxford, UK: Oxford University Press.
Fry B. G., Roelants K., Jackson T. N. W., Takacs Z., Reeks T., Kwok H. F.* (2015) Chapter 11 Exendin peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 247-254). Oxford, UK: Oxford University Press.
Zhang S. D., Leung K. L., McCrudden C. M., Kwok H. F.* (2015) The prognostic significance of combining VEGFA, FLT1 and KDR mRNA expressions in brain tumors. Journal of Cancer. 6: 812-818.
Huang Y., Zhang S. D., McCrudden C. M., Chan K. W., Lin Y., Kwok H. F.* (2015) The prognostic significance of PD-L1 in bladder cancer. Oncology Reports. 33: 3075-3084.
Zhang S. D., McCrudden C. M., Meng C., Lin Y*, Kwok H. F.* (2015) The significance of combining VEGFa, FLT1, and KDR expressions in colon cancer patient prognosis and predicting response to bevacizumab. OncoTargets and Therapy. 8: 835-843.
Neves H. and Kwok H. F.* (2015) Recent advances in the field of anti-cancer immunotherapy. BBA Clinical. 3: 280-288.
Xi X., Li B., Chen T., Kwok H. F.* (2015) A Review on Bradykinin-Related Peptides Isolated from Amphibian Skin Secretion. Toxins. 7(3): 951-970.
Kwok H .F.*, Zhang S. D., McCrudden C. M., Yuen H. F., Ting K. P., Wen Q., Khoo U.S.*, Chan K. Y. K.* (2015) Prognostic significance of minichromosome maintenance proteins in breast cancer. American Journal of Cancer Research. 5(1): 52-71.
Huang Y., Benaich B., Tape C. J., Kwok H. F.*, Murphy G.* (2014) Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation. International Journal of Biological Sciences. 10(7): 702-714.
Kwok H. F.*, Botkjaer K. A., Tape C. J., Huang Y., McCafferty J., Murphy G. (2014) Development of a ‘mouse and human cross-reactive’ affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy. PEDS 27(6): 179-190.

*corresponding author

^co-first author